Equity in genetic newborn screening

State‐level newborn screening allows for early treatment of genetic disorders, which can substantially improve health outcomes for newborns. As the cost of genetic testing decreases, it is becoming an essential part of newborn screening. A genetic disorder can be caused by many mutation variants; therefore, an important decision is to determine which variants to search for (ie, the panel design), under a testing budget. The frequency of variants that cause a disorder and the incidence of the disorder vary by racial/ethnic group. Consequently, it is important to consider equity issues in panel design, so as to reduce disparities among different groups. We study the panel design problem using cystic fibrosis (CF) as a model disorder, considering the trade‐offs between equity and accuracy, under a limited budget. Most states use a genetic test in their CF screening protocol, but panel designs vary, and, due to cost, no state's panel includes all CF‐causing variants. We develop models that design equitable genetic testing panels, and compare them with panels that maximize sensitivity in the general population. Our case study, based on realistic CF data, highlights the value of equitable panels and provides important insight for newborn screening practices.     

卫星地面站自动测试软件的“三化”设计

应用MVC设计模式,采用PIM应用架构,通过动态链接库和构件技术,对卫星地面站自动测试软件进行了通用化、系列化和组合化设计。     

基于假设检验的编队组织决策设计

从集中式和分散式组织结构分析出发,采用假设检验的方法,探讨了分布式结构假设检验在海军舰艇编队环境评估中的组织决策设计,并从决策设计和算法上对其进行了复杂性分析.研究结果表明,基于假设检验的组织决策是一个NP问题,就存在的问题提出算法和组织设计研究的思路.     

军用软件的测试与实践方法

首先分析了民用软件存在的问题,然后结合军用软件的特点,对影响军用软件可靠性的因素进行分析,最后提出提高军用软件质量的几种测试与实践方法.     

舰空导弹武器系统软件靶场综合测试分析

针对舰空导弹武器系统的特点以及舰空导弹武器系统软件定型试验的现状,指出了舰空导弹武器系统软件靶场测试的必要性、特殊性。通过靶场软件测试综合试验,总结了舰空导弹武器系统软件靶场定型的试验方法。并指出了靶场软件测试的发展方向。     

爆炸复合接头剪切强度测试方法研究

参照正交各向异性层压复合板层间剪切强度的测试方法,提出了用于测试爆炸复合接头复合界面剪切强度的3种方法;并建立三维有限元模型,分别对3种测试方法进行模拟;最后分别对3种方法进行了测试试验.结果表明,3种试验方法均能有效测试爆炸复合接头的剪切强度,其中对称试件双切口拉伸法最适合实际应用.     

基于EMD的改进小波阈值降噪法在超声信号处理中的应用

针对超声检测回波信号中的大量噪声,分析了超声检测回波信号的特性,考虑经验模式分解（EMD）和小波哗噪的优点,在改进阈值函数基础上提出一种基于EMD的小波阈值降噪方法．该方法利用EMD对超声信号进行分解,对高频分量用改进小波阈值函数方法进行处理,再结合低频分量重构得到降噪信号．仿真实验结果表明,该方法降噪效果优于小波软、硬阂值降噪,进一步提高了重建信号的信噪比,降低了其均方根误差,是一种可行的超声信号降噪方法．     

Comparison between constant‐stress and step‐stress accelerated life tests under Time Constraint

By running life tests at higher stress levels than normal operating conditions, accelerated life testing (ALT) quickly yields information on the lifetime distribution of a test unit. The lifetime at the design stress is then estimated through extrapolation using a regression model. In constant‐stress testing, a unit is tested at a fixed stress level until failure or the termination time point of test, whereas step‐stress testing allows the experimenter to gradually increase the stress levels at some prefixed time points during the test. In this work, the optimal k‐level constant‐stress and step‐stress ALTs are compared for the exponential failure data under complete sampling and Type‐I censoring. The objective is to quantify the advantage of using the step‐stress testing relative to the constant‐stress one. Assuming a log‐linear life–stress relationship with the cumulative exposure model for the effect of changing stress in step‐stress testing, the optimal design points are determined under C/D/A‐optimality criteria. The efficiency of step‐stress testing to constant‐stress one is then discussed in terms of the ratio of optimal objective functions based on the information matrix. © 2013 Wiley Periodicals, Inc. Naval Research Logistics 00: 000–000, 2013     

目标识别中的传感器管理方法

基于假设检验的方法,研究了目标识别中的传感器管理方法。分别以用于假设检验问题中的最大后验概率、最小代价函数和最大正确检测概率为目标函数,给出了用于目标识别问题的多传感器管理方法,并针对目标识别问题的特点,对其进行了相应的改进。通过对一定场景的仿真,比较了三种不同方法的识别正确率和平均采样次数,分析了各种方法的特点。     

航空电子总线测试系统的设计与实现

现代航空电子综合化系统通常建立在M IL-STD-1533B多路传输数据总线通信网络基础之上,总线控制器(BC)和各个远程终端(RT)必须满足M IL-STD-1553B规定的各项协议指标要求,才能正确地联网通讯。讨论了某型航空电子总线测试系统的设计与实现,主要探讨了此系统的软、硬件开发,系统组成及其BC和RT有效性测试的主要内容和要求。在实际应用中收到了很好的效果。